Skip to contents

A dataset from a systematic review of Randomised-Controlled Trials (RCTs) for maintenance treatment of moderate to severe chronic obstructive pulmonary disease (COPD) (Karabis et al. 2013) . Data are extracted from (Tallarita et al. 2019) . SEs were imputed for three studies, and number of patients randomised were imputed for one study (LAS 39) in which they were missing, using the median standard deviation calculated from other studies in the dataset. The outcome is trough Forced Expiratory Volume in 1 second (FEV1), measured in litres and reported in each study arm as mean change from baseline to follow-up. The dataset includes 13 Randomised-Controlled Trials (RCTs), comparing 2 treatments (Tiotropium and Aclidinium) and placebo.




A data frame in long format (one row per arm and study), with 80 rows and 6 variables:

  • studyID Study identifiers

  • time Numeric data indicating the time at which the observation was measured (given in weeks)

  • y Numeric data indicating the mean change from baseline in FEV1 (litres) in a study arm

  • se Numeric data indicating the standard error for the mean change from baseline in FEV1 in a study arm

  • treatment Factor data indicating the treatment to which participants were randomised

  • n Numeric data indicating the number of participants randomised to each arm


copd is a data frame in long format (one row per observation, arm and study), with the variables studyID, time, y, se, treatment, and n.


Karabis A, Lindner L, Mocarski M, Huisman E, Greening A (2013). “Comparative efficacy of aclidinium versus glycopyrronium and tiotropium, as maintenance treatment of moderate to severe COPD patients: a systematic review and network meta-analysis.” Int J Chron Obstruct Pulmon Dis, 8, 405-423. doi:10.2147/COPD.S48967 ,

Tallarita M, De lorio M, Baio G (2019). “A comparative review of network meta-analysis models in longitudinal randomized controlled trial.” Statistics in Medicine, 38(16), 3053-3072. doi:10.1002/sim.8169 .